Malefu Meaning in English. What is the meaning of Malefu? by names Malefu: Sotho origin, meaning “mother of the house.” Famous People: Malefu Molefe – South African actress. Malefu Ntshangase – South African singer. Malefu Sehloho – Lesotho poet. π SEARCH π+ ADD CLAN NAMESβΆ UTube Channel