Nomzamo Mbatha was born on 13 July 1990 in KwaMashu Township, approximately 21 kilometres (13 mi), by road, north-west of the city of Durban, in KwaZulu Natal Province and is of Zulu ethnicity.

She attended Rippon Primary School in Durban and Bechet High School, where she obtained her High School Diploma. In 2018, she graduated from the University of Cape Town with a Bachelor of Commerce degree specializing in accounting.

Mbatha auditioned for a television show in July 2012. She also started acting on Isibaya and also became the main character. The search, which was held at Cape Town, attracted over 600 contestants. She placed in the top 70 and later the top 10. She was one of the three top finalists. In 2014, the show in which Mbatha starred was converted into a daily Tell Me Sweet Something, and a television show Umlilo. That same year, she began hosting a reality travel show called “Holiday Swap”, on South African Broadcasting Corporation.

In 2015, she was selected to represent Neutrogena, being the first South African in that role.

In 2021, she appeared in the film Coming 2 America.

The previous year, Mbatha signed with talent management agency Creative Artists Agency.